Product overview

• NameCaM Kinase II (290-309), Calmodulin Antagonist
• Short descriptionPotent, competitive CaMKII inhibitor
• Biological descriptionPotent and competitive CaMKII inhibitor (IC₅₀ = 52 nM). Acts as a pseudosubstrate at the catalytic core of the enzyme. Reduces Ca²⁺-dependent Cl^- current in T84 cells by approx. 70%, but does not affect Cl^- channels in parotid acinar cells.
• Biological actionInhibitor
• Purity>97%
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Properties

• Chemical nameCa2+/calmodulin-dependent protein kinase II (290-309)
• Molecular Weight2273.8
• Molecular FormulaC₁₀₃H₁₈₅N₃₁O₂₄S
• CAS Number115044-69-4
• PubChem identifier22114573
• SMILESCCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)N

Storing and Using Your Product

• Solubility overviewsoluble in water
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CaM Kinase II (290-309), Calmodulin Antagonist

• Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.

  Payne ME et al (1988)J Biol Chem 263(15) : 7190-5. PubMedID: 2835367

• Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II.

  Mukherji S et al (1995)J Biol Chem 270(23) : 14062-7. PubMedID: 7775466

• Characteristics of the inhibitory effect of calmodulin on specific [125i]omega-conotoxin GVIA binding to crude membranes from chick brain.

  Ichida S et al (2000)Neurochem Res 25(12) : 1629-35. PubMedID: 11152392