ReliaTech/Mouse Anti-Mouse VEGFR-3/FLT-4, Antagonistic/mV1003m-m/200 µg

来自 : 发布时间：2024-12-22

Clone/AB feature:

(#9G03)

Antibody generation:

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with mouse VEGFR3 N-terminal recombinant protein.

Antigen:

recombinant mouse VEGFR3 N-terminal protein

Stability:

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.

Description:

VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.